Djokovic, Sharapova cruise at Aussie Open

Serbia's Novak Djokovic makes a forehand return to Ryan Harrison of the US during their second round match at the Australian Open tennis championship in Melbourne, Australia, Wednesday, Jan. 16, 2013. (AP Photo/Rob Griffith)

Serbia's Novak Djokovic makes a forehand return to Ryan Harrison of the US during their second round match at the Australian Open tennis championship in Melbourne, Australia, Wednesday, Jan. 16, 2013. (AP Photo/Rob Griffith)

Russia's Maria Sharapova hits a return to Japan's Misaki Doi during their second round match at the Australian Open tennis championship in Melbourne, Australia, Wednesday, Jan. 16, 2013. (AP Photo/Rob Griffith)

Venus Williams of the US hits a forehand to France's Alize Cornet during their second round match at the Australian Open tennis championship in Melbourne, Australia, Wednesday, Jan. 16, 2013. (AP Photo/Rob Griffith)

Russia's Maria Sharapova waves to the crowd after defeating Japan's Misaki Doi during their second round match at the Australian Open tennis championship in Melbourne, Australia, Wednesday, Jan. 16, 2013. (AP Photo/Rob Griffith)

Australia's Samantha Stosur wipes the sweat from her face during her second round match against China's Zheng Jie at the Australian Open tennis championship in Melbourne, Australia, Wednesday, Jan. 16, 2013. (AP Photo/Andy Wong)

MELBOURNE, Australia (AP) ? Novak Djokovic was all but perfect in his second-round match Wednesday against Ryan Harrison, beating the 20-year-old American 6-1, 6-2, 6-3 to stay on track for his third consecutive Australian Open title and the fourth of his career.

Maria Sharapova was even more convincing a few hours earlier, winning 6-0, 6-0 for the second time in two matches to set up a third-round encounter with Venus Williams.

Williams beat Alize Cornet 6-3, 6-3 in the match preceding the Djokovic-Harrison encounter at Rod Laver Arena, which will be the likely venue for her big matchup Friday against Sharapova.

Reigning French Open champion Sharapova holds a 4-3 edge in career meetings, but Williams has won both of their meetings at Grand Slam tournaments ? at Wimbledon in 2005 and 2007.

Venus' sister Serena, playing in the other half of the draw, had the day off Wednesday and was able to rest the right ankle she injured in her first-round match. She's set to play Garbine Muguruza on Thursday as she pursues her own sequence of three. She won Wimbledon and the U.S. Open last year and is aiming for a third major in a row.

Djokovic, a loser in the U.S. Open final last year to Andy Murray, looks like he wants to atone for that defeat. He was relentless in beating the overmatched Harrison, winning the first set in just 20 minutes and the match in 1? hours while making just 16 unforced errors.

"I tried to focus from the start," Djokovic said. "Obviously, I knew he had nothing to lose, he's going to come out and hit big serves. Pity for him, I don't think he played his best."

Sharapova did, particularly for someone who has precious little match "toughness" heading into the Australian Open. The second-seeded Russian beat Japan's Misaki Doi by the double-bagel score in just 47 minutes, her second consecutive match at Melbourne Park in which her opponent failed to win a game. Doi won only 15 points.

Sharapova, last year's Australian Open runner-up, pulled out of the Brisbane International with a right collarbone injury two weeks ago and had not played a competitive match this year until her 6-0, 6-0 win over fellow Russian Olga Puchkova in the first round Monday.

She is the first woman to post consecutive 6-0, 6-0 scorelines at a Grand Slam since Wendy Turnbull at the Australian Open in 1985.

"I've been playing really aggressive and doing the right things," Sharapova said. "It's not easy to be up so much because you can have a few letdowns. You just have to try to concentrate. My job is to make it as easy as possible."

Venus Williams took advantage of Cornet's double-fault to end the first set.

"Tennis ... is about winning when it's not your best day," the 25th-seeded Williams said. Next up "I'm playing against Maria. I'm going to have to be at my best against her."

The final match of Wednesday's session on the center court was disappointing, though not wholly unexpected, for the home crowd and Australia's top-ranked female player.

Ninth-seeded Samantha Stosur, who has spoken of her anxiety over playing in front of her home fans, served twice for the match but double-faulted on match point in a 6-4, 1-6, 7-5 loss to China's Zheng Jie.

"It was a bit of a choke," Stosur admitted. "Obviously it's a hard one to take when you get yourself into a winning position and you lose five games straight."

Stosur, who had nine double-faults and 56 unforced errors, has never gone beyond the fourth round at her home Grand Slam, lost in the first round last year and also lost in her first matches at warm-up tournaments this year in Brisbane and Sydney.

"I needed to keep fighting and enjoy the match," Zheng said. "It's amazing I came back."

Earlier, fourth-seeded Agnieszka Radwanksa extended the year's best winning streak to 11 matches. She eased into the third round with a 6-3, 6-3 victory over Romania's Irina-Camelia Begu and remains unbeaten this year, including titles at warm-up tournaments this month at Auckland and Sydney.

"I can play even better," said Radwanska, who lost last year's Wimbledon final to Serena Williams. "I didn't really expect I could win that many matches in a row, and hopefully I can keep going."

Her last two trips to the Australian Open have ended in quarterfinal losses to the eventual champion ? Kim Clijsters in 2011 and Victoria Azarenka last year.

With top-ranked Azarenka and Serena Williams on the other half of the draw, Radwanska's main obstacles to reaching the final are 2011 French Open champion Li Na, who beat Olga Goortsova of Belarus 6-2, 7-5 to reach the third round, and potential semifinal rivals Sharapova or No. 5 Angelique Kerber, who advanced with a 6-3, 6-1 win over Lucie Hradecka.

Serena Williams, who has lost only one match since her first-round exit at the French Open last year, canceled an outdoor practice session and moved it indoors to test out her sore ankle.

In other women's second-round matches: No. 11 Marion Bartoli beat Serbian qualifier Vesna Dolonc 7-5, 6-0; No. 13 Ana Ivanovic had a 7-5, 1-6, 6-4 win over Taiwanese qualifier Chan Yung-jan; No. 18 Julia Gorges beat Romina Oprandi 6-3, 6-2; No. 22 Jelena Jankovic, a former world No. 1, beat qualifier Maria Joao Koehler 2-6, 7-6 (5), 6-2; and 17-year-old American wild-card Madison Keys beat No. 30 Tamira Paszek of Austria 6-2, 6-1.

Russian qualifier Valeria Savinykh upset No. 15 Dominika Cibulkova 7-6 (6), 6-4 and Kirsten Flipkens of Belgium beat No. 23 Klara Zakopalova 6-1, 6-0.

On the men's side, No. 4-ranked David Ferrer needed five match points before clinching a 6-0, 7-5, 4-6, 6-3 win over American Tim Smyczek, who got into the main draw as a lucky loser from qualifying.

Fifth-seeded Tomas Berdych beat Guillaume Rufin of France 6-2, 6-2, 6-4 and eighth-seeded Janko Tipsarevic beat Lukas Lacko 6-3, 6-4, 3-6, 4-6, 7-5 in a match that lasted nearly four hours.

No. 10 Nicolas Almagro and No. 16-ranked Kei Nishikori also moved on while No. 24 Jerzy Janowicz of Poland rallied from two sets down to overpower India's Somdev Devvarman 6-7 (10), 3-6, 6-1, 6-0, 7-5.

Also advancing were No. 22 Fernando Verdasco, No. 28 Marcos Baghdatis, the 2006 Australian Open runner-up, No. 31 Radek Stepanek and No. 32 Julien Benneteau. Stepanek beat Feliciano Lopez 6-2, 6-2, 6-4 and will next play Djokovic.

No. 20 Sam Querrey advanced when fellow American Brian Baker retired in the second set with a right knee injury and next plays No. 15 Stanislas Wawrinka.

Baker, who returned to the tour last year after missing almost six seasons with a variety of injuries, won a first-set tiebreaker and was level at 1-1 on serve in the second. He was later pushed from Court 6 in a wheelchair.

Tournament organizers said that Baker had a torn meniscus and is expected to be out about four months.

"Yeah, he's the last person that deserves anything like that with his five or six surgeries already," Querrey said.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-01-16-TEN-Australian-Open/id-0c5af3f06d074036b760892a686aba56

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11 Firms In Running For Mass. Gambling Facilities ? CBS Boston

BOSTON (CBS/AP) ? The Massachusetts Gaming Commission says a total of 11 companies seeking to develop a resort casino or slots parlor in Massachusetts have submitted preliminary applications along with $400,000 nonrefundable entry fees.

Among those beating a 5 p.m. deadline on Tuesday was a group seeking to build a casino in the town of Milford.

A surprise last-minute entry was a company affiliated with the principals of Baltimore-based Cornish Companies. PPE Casino Resorts said in a statement that it had not yet chosen a location or decided whether it planned to bid for a resort casino or slots parlor.

Massachusetts Gaming & Entertainment, an affiliate of Chicago-based Rush Street Gaming, also applied on Tuesday but said it had not yet chosen a location.

A group hoping for a slots parlor at Raynham Park also beat the deadline.

The MGC received applications from the following entities:

• MGM Springfield
• Penn National Gaming, Inc.
• Plainridge Racecourse
• Hard Rock MA
• Wynn, LLC
• Mohegan Sun
• Sterling Suffolk Racecourse
• Raynham Park
• Mass Gaming & Entertainment, LLC
• PPE Casino Resorts
• Crossroads Massachusetts, LLC

(TM and ? Copyright 2013 CBS Radio Inc. and its relevant subsidiaries. CBS RADIO and EYE Logo TM and Copyright 2011 CBS Broadcasting Inc. Used under license. All Rights Reserved. This material may not be published, broadcast, rewritten, or redistributed. The Associated Press contributed to this report.)

Source: http://boston.cbslocal.com/2013/01/15/deadline-arrives-for-firms-seeking-mass-casinos/

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Lilly 2013 profit forecast tops expectations

INDIANAPOLIS (AP) ? Eli Lilly and Co. unveiled a better-than-expected 2013 earnings forecast Friday, in part because the pharmaceutical company expects growth from several established drugs to help make up for revenue lost to generic competition.

The Indianapolis drug developer saw sales for its all-time best-selling drug, the antipsychotics Zyprexa, crater in 2012 after it lost U.S. patent protection. Lilly will take another hit next December when it loses patent protection for its current top seller, the antidepressant Cymbalta.

But company executives told analysts Friday they still expect Cymbalta and another product that loses patent protection in 2013, the insulin Humalog, to help drive revenue growth along with products like the cancer treatment Alimta and the erectile dysfunction drug Cialis.

Lilly also expects more growth from Japan, developing countries and its animal health business.

All told, the drugmaker forecast 2013 adjusted earnings of between $3.75 and $3.90 per share on $22.6 billion to $23.4 billion in revenue.

That topped analyst expectations, on average, for earnings of $3.72, according to FactSet. Analysts also expected $22.87 billion in revenue.

Company shares climbed $1.71, or 3.4 percent, to $51.43 in Friday afternoon trading, while broader indexes rose less than 1 percent.

Lilly said it expects operating expenses will be flat or drop slightly compared with 2012, and that was slightly better than what Edward Jones analyst Judson Clark expected.

He called Lilly's 2013 forecast "a pleasant surprise," but he also noted that plenty of long-term concerns remain. Lilly won't feel the brunt of the Cymbalta patent loss until 2014, and Clark expects the company's earnings to shrink then. What remains to be seen, he said, is whether the drugmaker is willing to preserve its dividend and cut expenses enough to tame that loss.

"We think the real question marks are in 2014," he said.

Lilly also expects to counter the patent expirations by developing new drugs, and the company said Friday it has 13 experimental drugs in late-stage testing, the last phase before a company seeks regulatory approval.

Lilly reiterated on Friday that it expects at least $3 billion in net income and revenue of at least $20 billion through 2014. It also expects to keep paying its dividend and to buy back $1.5 billion in shares this year.

Zyprexa once brought in more than $5 billion in annual revenue for Lilly, but its sales sank 66 percent through the first nine months of 2012 after generic competition entered the market. The company expects revenue from Cymbalta, which topped $4 billion in 2011, to start falling in this year's fourth quarter.

Humalog, Lilly's best-selling insulin, brought in about $1.4 billion in U.S. revenue in 2011. That product may take less of a sales hit after it loses U.S. patent protection in May because it's a biologic drug made from living cells instead of a chemical formula. Those are harder for generic drugmakers to replicate.

Lilly should not expect to replace blockbuster drug revenue with another round of blockbusters, said WBB Securities analyst Steve Brozak. He said the company's success will depend on a combination of drug development, partnerships with other companies and acquisitions that help stoke its product pipeline.

But that approach will be difficult because other drugmakers also are facing patent expirations and will be competing with Lilly on those deals.

"If (Lilly executives) think that business as usual applies, their shareholders are going to vote with their sell orders," he said.

The company reports fourth-quarter and 2012 results Jan. 29.

Source: http://news.yahoo.com/lilly-2013-profit-forecast-tops-expectations-130042995--finance.html

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Multiple Sclerosis Blog - Everyday Health

Sometimes MS can do things to our bodies that make us wish we could just check out of them for a little while. Other times, however, I find myself a few feet away and it freaks me out!

It happens most often if I am sitting and typing at my laptop for a while. Not all of the time; not even much of the time. This sensation only comes over me as an MS ?thing? is about to happen (or is already underway). I get the sense that I am somehow about six inches behind and about three inches above my body.

I almost want to reach out further in order to touch the keys as the feeling is so strong and so real.

This stretch in consciousness is usually accompanied with a tunneling in my sense of hearing as if my brain is that same distance behind my ears. I can move my head around a bit and shake the feeling for a bit, but then it comes back and doesn?t leave. Profound fatigue is at the doorstep by this point and it?s time to find a place sleep before the place I am becomes that place.

The other night, after such an experience at our dining room table, I headed off to bed to await what MS might take from me in the night. During an unusual trip to pee in the night (the sleep which usually follows these out of body things is usually anesthesia-like) I had my first standing outside the body experience since my diagnosing attack.

Rather than being pulled back and up, this time I felt as if my awareness was about nine inches taller than myself and only a bit behind (maybe a couple of inches). It was the weirdest thing; holding onto a wall on one side and the shower on the other and almost looking down on myself from above.

There is sometimes a slight dizziness with this experience. Not a nauseating, spinning kind of dizzy but more a mild earthquake kind of feeling. The room, however, doesn?t shift; it?s my sense of being that takes a rumbling.

As we?ve shared the weird, the frustrating and the scary symptoms of MS here for more years than many of us care to remember, I thought I?d share this one. Anyone else have these feelings that you are leaving your body (or that MS is somehow kicking you out)?

Wishing you and your family the best of health.

Cheers

Trevis

You can also follow me via our Life With MS Facebook page, on Twitter, and in our group on MS Connection.org. Also, check out our bi-monthly MS blog for the United Kingdom, look for our very special new monthly blog for the National MS Society, and don?t forget to check out TrevisLGleason.com.

Source: http://www.everydayhealth.com/blog/trevis-life-with-multiple-sclerosis-ms/multiple-sclerosis-out-of-body-experience/

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DOMESTIC VIOLENCE IN RELATIONSHIPS!! IS IT RIGHT!!! 01/09 ...

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Host Barry Moltz gets small businesses unstuck. He has founded and run small businesses with a great deal of success and failure for more than 15 years. This is a business radio show where he shares all the craziness of small business. It?s that craziness that actually makes it exciting, interesting and totally unpredictable.

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Deepak Chopra Radio provides an online forum for compelling and thought provoking conversations on success, love, sexuality and relationships, well-being and spirituality.

Hits Radio covers basketball, sports culture and entertainment with past guests including Jason Kidd, Robin Lundberg and Chris Herren.

Listeners get an earful on The Halli Casser-Jayne Show, Talk Radio for Fine Minds. Whether it?s the current political cocktail or the latest must-read award-winning book, Halli tackles all topics and likes to stir ? and sometimes shakes ? things up.

Official Internet radio show of forthcoming epic paranormal investigation book by Eric Olsen and "Haunted Housewife" Theresa Argie.

Award-winning World Footprints is a leading voice in socially responsible travel and lifestyle. Hosts Ian & Tonya celebrate culture and heritage and bring a unique voice to the world of travel.

Football Reporters Online is a group of veteran football experts in the fields of coaching, scouting, talent evaluation, and writing/broadcasting/media placement. Combined, the group brings well over 100 years of expertise in sports.

Host John Martin interviews the nation's leading entrepreneurs and small biz experts to educate small business owners on how to be successful. Past guests have included Emeril Lagasse and Guy Kawasaki.

The Movie Geeks share their passion for the art through interviews with the stars of and creative minds behind your favorite flicks and pay tribute to big-screen legends. From James Cameron and Francis Ford Coppola to Ellen Burstyn and Robert Duvall, The Geeks have got'em all.

Sylvia Global presents global conversations pertaining to women, wealth, business, faith and philanthropy. Sylvia has interviewed an eclectic mix from CEOs and musicians to fashion designers and philanthropists including Randolph Duke and Ne-Yo.

Mr. Media host Bob Andelman goes one-on-one with the hottest, most influential minds from the worlds of film, TV, music, comedy, journalism and literature. That means A-listers like Kirk Douglas, Christian Slater, Kathy Ireland, Rick Fox, Chris Hansen and Jackie Collins.

Paula Begoun, best-selling author of Don't Go to the Cosmetics Counter Without Me, separates fact from fiction on achieving a radiant, youthful complexion at any age. She?s regularly joined by health and beauty experts who offer the latest on keeping your skin in tip-top shape.

Source: http://www.blogtalkradio.com/chloesbrainstorming/2013/01/10/domestic-violence-in-relationships-is-it-right

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Rainfall, brain infection linked in sub-Saharan Africa

Jan. 4, 2013 ? The amount of rainfall affects the number of infant infections leading to hydrocephalus in Uganda, according to a team of researchers who are the first to demonstrate that these brain infections are linked to climate.

Hydrocephalus -- literally "water on the brain" -- is characterized by the build-up of the fluid that is normally within and surrounding the brain, leading to brain swelling. The swelling will cause brain damage or death if not treated. Even if treated, there is only a one-third chance of a child maintaining a normal life after post-infectious hydrocephalus develops, and that chance is dependent on whether the child has received the best treatment possible.

"The most common need for a child to require neurosurgery around the world is hydrocephalus," said Steven J. Schiff, the Brush Chair Professor of Engineering, director of the Penn State Center for Neural Engineering and a team member.

In sub-Saharan Africa, upward of 100,000 cases of post-infectious hydrocephalus a year are estimated to occur. The majority of these cases occur after a newborn has suffered from neonatal sepsis, a blood infection that occurs within the first four weeks of life, the researchers reported in a recent issue of the Journal of Neurosurgery: Pediatrics.

Benjamin C. Warf, associate professor of neurosurgery, Harvard Medical School, Boston Children's Hospital, noticed that about three or four months after an infant in East Africa had an infection like neonatal sepsis, the child would often return to the clinic with a rapidly growing head -- hydrocephalus. Schiff joined Warf to help figure out what caused this disease so frequently.

Schiff and colleagues tracked 696 hydrocephalus cases in Ugandan infants between the years 2000 and 2005. The researchers obtained localized rainfall data for the same time frame through NOAA (National Oceanic and Atmospheric Administration) weather satellites using the African Rainfall Estimation Algorithm developed at the U.S. NOAA Climate Prediction Center.

Uganda has two peak rainfall seasons, in spring and fall. By comparing the data from NOAA and the hydrocephalus cases, the researchers found that instances of the disorder rose significantly at four different times throughout the year -- before and after the peak of each rainy season, when the amount of rainfall was at intermediate levels. In Uganda an intermediate rainfall is about 6 inches of rain per month.

Schiff and colleagues previously noted that different bacteria appear associated with post-infectious hydrocephalus at different seasons of the year. While the researchers have not yet characterized the full spectrum of bacteria causing hydrocephalus in so many infants, they note that environmental conditions affect conditions supporting bacterial growth, and that the amount of rain can quench bacterial infections. The moisture level clearly affects the number of cases of hydrocephalus in this region of East Africa.

"Hydrocephalus is the first major neurosurgical condition linked to climate," said Schiff, who is also professor of neurosurgery, engineering science and mechanics, and physics, and a faculty member of the Huck Institutes of the Life Sciences. "This means that a substantial component of these cases are almost certainly driven from the environmental conditions, and that means they are potentially preventable if we understand the routes and mechanisms of infection better."

Other members of the research team were Sylvia L. Ranjeva, who was then a Penn State Schreyer Honors College undergraduate and now at the University of Chicago Medical School, and Timothy D. Sauer, professor of mathematics, George Mason University.

The Penn State Clinical and Translational Sciences Institute; the Pennsylvania Department of Health, Commonwealth Universal Research Enhancement (CURE) Program; and the Harvey F. Brush Endowment funds supported this work.

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Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/Zb-cq4d-9pI/130104143652.htm

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An embryo that is neither male nor female: Impact of three unexpected sex determination factors analyzed

Jan. 3, 2013 ? So, is it a girl or a boy? This is the first question parents ask at the birth of an infant. Though the answer is obvious, the mechanism of sex determination is much less so. Researchers at the University of Geneva (UNIGE) attempt to shed light on this complex process by identifying the crucial role played by insulin and IGF1 and IGF2 growth factors, a family of hormones known for its role in metabolism and growth. In the absence of these factors at the time of sex determination, embryos do not differentiate into either male or female and have no adrenal glands. The results of this study, published in the journal PLOS Genetics, allow us to better understand sexual development and will eventually improve diagnosis and genetic counseling practices for individuals with disorders of sex development.

In mammals, sexual development is a long process beginning at conception when the sperm's transmission of an X or Y sex chromosome will determine the genetic sex of the embryo. The following developmental stages will translate this genetic sex into gonadal sex, that is, either ovaries or testes, which will secrete hormones that will masculinize or feminize the fetus.

The intention of the study conducted by Serge Nef, Professor at the Department of Genetic Medicine and Development at UNIGE, is to better understand the first stages of sexual development.

Growth, metabolism and reproduction

The researchers were interested in the role of a class of hormones, insulin-like growth factors (IGFs), and their receptors in cells. These factors, known to be involved in the regulation of metabolism and growth, also have a key role in the regulation of reproductive capacities of the individual, whether male or female. Reproductive function is, in fact, closely linked to metabolism and growth. This is actually quite logical: the growth of an individual cannot progress normally without adequate energy intake and there is no point in reproducing if this caloric intake is insufficient. This may explain why some women with anorexia have anovulatory cycles and may suffer from infertility. Conversely, people with morbid obesity also have significant disturbances in their fertility. Though it is now recognized that the interactions between metabolism, growth and reproductive capacity are regulated by common factors such as insulin and IGFs, Professor Nef's study shows that these interactions are even more important than previously believed because the insulin and IGF receptors are also essential for primary sex determination in mammals.

To analyze the impact of these hormones on sex determination, Professor Nef's group used genetically modified mice. The scientists genetically inactivated the receptors for insulin and IGFs in mouse embryos. They then discovered that in the absence of these factors, at the time of sex determination, the gonads of mutant embryos were unable to develop into testes or ovaries. As such, the embryo and its gonads remained stuck in a fully undifferentiated state for several days demonstrating the essential role of these hormones and growth factors in sexual differentiation.

In humans, cases of disorders of sex development are relatively common with about 1 newborn in every 3000 births being affected. Unfortunately, in the majority of cases, the genetic causes of such alterations remain unexplained. "This study provides a better understanding of the basic mechanisms of sexual development and is a step forward towards a better understanding of the causes of sexual ambiguities, which often remain unknown," states Professor Nef. "The research we are conducting will provide the opportunity to refine and improve clinical diagnosis of individuals with disorders of sex development."

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Journal Reference:

1. Jean-Luc Pitetti, Pierre Calvel, Yannick Romero, B?atrice Conne, Vy Truong, Marilena D. Papaioannou, Olivier Schaad, Myl?ne Docquier, Pedro Luis Herrera, Dagmar Wilhelm, Serge Nef. Insulin and IGF1 Receptors Are Essential for XX and XY Gonadal Differentiation and Adrenal Development in Mice. PLoS Genetics, 2013 DOI: 10.1371/journal.pgen.1003160

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/qL7WE4WuASg/130103192445.htm

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Scientists discover that for Australia the long-beaked echidna may not be a thing of the past

Scientists discover that for Australia the long-beaked echidna may not be a thing of the past

Thursday, January 3, 2013

The western long-beaked echidna, one of the world's five egg-laying species of mammal, became extinct in Australia thousands of years ago?or did it? Smithsonian scientists and colleagues have found evidence suggesting that not only did these animals survive in Australia far longer than previously thought, but that they may very well still exist in parts of the country today. The team's findings are published in the Dec. 28, 2012 issue of the journal ZooKeys.

With a small and declining population confined to the Indonesian portion of the island of New Guinea, the western long-beaked echidna (Zaglossus bruijnii) is listed as "Critically Endangered" on the International Union for Conservation of Nature's Red List of Threatened Species. It is also considered extinct in Australia, where fossil remains from the Pleistocene epoch demonstrate that it did occur there tens of thousands of years ago. Ancient Aboriginal rock art also supports the species' former presence in Australia. However, no modern record from Australia was known to exist until scientists took a closer look at one particular specimen stored in cabinets in the collections of the Natural History Museum in London. Previously overlooked, the specimen's information showed that it was collected from the wild in northwestern Australia in 1901?thousands of years after they were thought to have gone extinct there.

"Sometimes while working in museums, I find specimens that turn out to be previously undocumented species," said Kristofer Helgen of the Smithsonian Institution, the lead author and the scientist to first report the significance of the echidna specimen. "But in many ways, finding a specimen like this, of such an iconic animal, with such clear documentation from such an unexpected place, is even more exciting."

Long-beaked echidnas are known as monotremes?a small and primitive order of mammals that lay eggs rather than give birth to live young. The platypus, the short-beaked echidna, and the three species of long-beaked echidna (Western, Eastern and Sir David Attenborough's) are the only monotremes that still exist. The platypus is found only in eastern Australia, the short-beaked echidna is found in Australia and New Guinea, and the long-beaked echidnas were previously known as living animals only from the island of New Guinea. Long-beaked echidnas, which grow to twice the size of the platypus or the short-beaked echidna, are beach-ball sized mammals covered in coarse blackish-brown hair and spines. They use their long, tubular snout to root for invertebrates in the forests and meadows of New Guinea. Among many peculiar attributes, reproduction is one of the most unique?females lay a single leathery egg directly into their pouch where it hatches in about 10 days.

The re-examined specimen in London reveals that the species was reproducing in Australia at least until the early 20th century. It was collected in the West Kimberley region of Western Australia by naturalist John T. Tunney in 1901, on a collecting expedition for the private museum of Lord L. Walter Rothschild in England. Despite collecting many species of butterflies, birds and mammals (some new to science at the time), no full report on his specimens has ever been published. The collection, including the long-beaked echidna specimen, was then transferred to the Natural History Museum in London in 1939 after Rothschild's death. It was another 70 years before Helgen visited the museum in London and came across the specimen with the original Tunney labels, which both challenged previous thinking about the species' recent distribution and offered insight into where it may still occur.

"The discovery of the western long-beaked echidna in Australia is astonishing," said Professor Tim Flannery of Macquarie University in Sydney, referring to the new study. "It highlights the importance of museum collections, and how much there is still to learn about Australia's fauna."

Learning whether the western long-beaked echidna still exists in Australia today will take time. "The next step will be an expedition to search for this animal," Helgen said. "We'll need to look carefully in the right habitats to determine where it held on, and for how long, and if any are still out there." To find it, Helgen hopes to draw on his experience with the species in New Guinea and to interview those who know the northern Australian bush best. "We believe there may be memories of this animal among Aboriginal communities, and we'd like to learn as much about that as we can," he said.

With the species in danger of extinction, finding Australian survivors or understanding why and when they vanished is an important scientific goal. "We hold out hope that somewhere in Australia, long-beaked echidnas still lay their eggs," said Helgen.

###

Helgen KM, Miguez RP, Kohen JL, Helgen LE (2012) Twentieth century occurrence of the Long-Beaked Echidna Zaglossus bruijnii in the Kimberley region of Australia. ZooKeys 255: 103?132. doi: 10.3897/zookeys.255.3774

Pensoft Publishers: http://www.pensoft.net

Thanks to Pensoft Publishers for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/126108/Scientists_discover_that_for_Australia_the_long_beaked_echidna_may_not_be_a_thing_of_the_past

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Boat Insurance Comparison | The Fundamentalist

If you personal a boat then you ought to know that boats come with a range of marine associated hazards. That is why boat insurance is a bit far more complex than regular auto or residence insurance. In order to be in a position to do a correct boat insurance comparison you want to take into account all the marine connected dangers and particular items like the navigation limits, towing and liabilities.

The first thing one particular wants to do prior to they can correctly do a boat insurance comparison is to evaluate their wants. Very first of all you require to obviously establish what variety of boat you personal. Is your boat meant for comfort or is it a speed boat? You also want to specify where you typically want to sail your boat, whether or not it?s in coastal waters or in inland lakes, or international waters. Establishing all these issues is really important as this will influence the type of coverage you will call for. Other issues that you need to have to establish include the value of your watercraft, the length and the kind of boat hull. All this things are also essential in order to establish the insurance quotes.

In order to get a good boat insurance comparison you need to have to know what the attributes of the insurance policies are. You want to know whether or not the insurance policy gives road side help. It is important that your policy supplies such a function as in situation your watercraft is damaged due to specific causes like accidents or mechanical breakdown, the towing to a repair facility and the coverage for the repairing labor will be taken care of by the insurance firm. A great boating insurance must also include a collision and a comprehensive coverage. The collision coverage will be needed if your watercraft collides with another boat or an object. Coverage in case of fire, vandalism or theft will be provided by the extensive function.

The best location to do boat insurance comparison is probably on the internet. The world wide web gives an simple and quickly way to acquire all the data you need to have spending extremely much less time. All you need to do is to submit some facts about yourself and your watercraft and most insurance internet sites will automatically provide you with a personalized boat insurance comparison. You can compare any variety of watercraft beginning with a simple dingy to a super yacht. By doing so you not only save time but also income as numerous businesses offer crucial discounts if you get the policy on-line.

Source: http://thefundamentalist.net/boat-insurance-comparison/

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Avis To Acquire Zipcar - Business Insider

Zipcar, the popular car sharing service, is getting acquired by Avis Budget Group.

Avis has agreed to purchase the company for $12.25 per share, which is a monster 49 percent premium over Monday's closing price of $8.24.

Here's the statement from Avis:

PARSIPPANY, N.J. and CAMBRIDGE, Mass., Jan. 2, 2013 (GLOBE NEWSWIRE) -- Avis Budget Group, Inc. (Nasdaq:CAR) and Zipcar, Inc. (Nasdaq:ZIP), the world's leading car sharing network, today announced that Avis Budget Group has agreed to acquire Zipcar for $12.25 per share in cash, a 49% premium over the closing price on December 31, 2012, representing a total transaction value of approximately $500 million. The transaction is subject to approval by Zipcar shareholders and other customary closing conditions, and is expected to be completed in the spring of 2013.?The Boards of Directors of both companies unanimously approved the transaction, and Zipcar shareholders representing approximately 32% of the outstanding common stock have agreed to vote their shares in support of the transaction.

Car sharing has grown to be a nearly $400 million business in the United States and is expanding rapidly in major cities around the world.?Zipcar has led this industry, leading in innovation and world-class service.?Zipcar now has more than 760,000 members, known as Zipsters, with a market-leading presence in 20 major metropolitan areas in the United States, Canada and Europe, and fleet positioned at over 300 college and university campuses.?Zipcar has combined leading-edge technology, an outstanding customer experience, and clear brand messaging to develop strong loyalty and advocacy among its customers.

"By combining with Zipcar, we will significantly increase our growth potential, both in the United States and internationally, and will position our Company to better serve a greater variety of consumer and commercial transportation needs," said Ronald L. Nelson, Avis Budget Group chairman and chief executive officer.?"We see car sharing as highly complementary to traditional car rental, with rapid growth potential and representing a scalable opportunity for us as a combined company.?We expect to apply Avis Budget's experience and efficiencies of fleet management with Zipcar's proven, customer-friendly technology to accelerate the growth of the Zipcar brand and to provide more options for Zipsters in more places.?We also expect to leverage Zipcar's technology to expand mobility solutions under the Avis and Budget brands."

Avis Budget expects to generate $50 to $70 million in annual synergies as a result of the transaction.?In particular, Avis Budget expects significant cost reductions across the fleet life cycle (from procurement to operations and maintenance to disposition, as well as financing), in addition to savings from eliminating Zipcar's public-company costs.?Avis Budget also plans to achieve substantial cost savings by increasing fleet utilization across the two companies.?Significant revenue growth opportunities exist, including by leveraging Avis Budget's fleet to meet more of Zipsters' weekend demand, which is currently constrained by fleet availability.

These synergies, combined with the expected growth and rising profitability of Zipcar, are expected to make the transaction accretive to Avis Budget's earnings per share in the second year following the acquisition, excluding certain items and purchase-accounting effects.

"We are delighted to announce our intention to join the Avis Budget Group family of companies, and we believe this combination is a win across the board for our members, shareholders and employees. ?We will be well positioned to accelerate enhancements to the Zipcar member experience with more offers and additional services as well as an expanded network of locations," said Scott Griffith, chairman and chief executive officer of Zipcar.?"As the leading global provider of car sharing services, with a brand that is synonymous with the category, we remain committed to the values and vision that have driven us forward for many years, grounded by our passion for delivering a superior experience to every member for every trip, every day.? By combining Zipcar's expertise in on-demand mobility with Avis Budget Group's expertise in global fleet operations and vast global network, we will be able to accelerate the revolution we began in personal mobility."

"Avis Budget's existing infrastructure, scale and experience with managing multiple brands make us uniquely positioned to accelerate the growth and profitability of Zipcar," Mr. Nelson added.?"At the same time, we are committed to retaining the elements of the Zipcar brand and culture that have allowed Zipcar to achieve such rapid growth and success over the last twelve years."

Following the acquisition, Zipcar will operate as a subsidiary of Avis Budget Group and will continue with its planned move to new headquarters in Boston, Massachusetts.?Avis Budget anticipates that key members of the Zipcar management team, including Mr. Griffith and Mark Norman, president and chief operating officer, will continue to set the overall direction and run day-to-day operations of Zipcar.

Avis Budget Group expects to fund the purchase price primarily with incremental corporate debt borrowings, as well as available cash.?As of September 30, 2012, Avis Budget Group had cash and marketable securities of approximately $554 million, and Zipcar had cash and marketable securities of approximately $82 million, or approximately $2 per Zipcar share.

Citigroup is acting as financial advisor, and Kirkland & Ellis LLP is acting as legal counsel, to Avis Budget Group.?Morgan Stanley is acting as financial advisor, and Latham & Watkins LLP is acting as legal counsel, to Zipcar.

Separately, Avis Budget Group today reiterated its previous estimates of its full-year 2012 results.?Avis Budget continues to expect that its full-year 2012 revenue will be approximately $7.3 billion, a 24% increase compared to 2011, and that its 2012 Adjusted EBITDA will be approximately $825 million to $840 million, excluding certain items, an increase of 35% to 38% compared to the prior year.?Avis Budget also continues to expect that its 2012 pretax income will be $450 million to $465 million and that its diluted earnings per share will be approximately $2.35 to $2.45, excluding certain items.

Source: http://www.businessinsider.com/avis-to-acquire-zipcar-2013-1

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Jennifer Lawrence Covers Vanity Fair, Voted World's Most Desirable Woman

Source: http://www.thehollywoodgossip.com/2013/01/jennifer-lawrence-covers-vanity-fair-voted-worlds-most-desirable/

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Meat sauce from Italy satisfies - Food - The Olympian - Olympia ...

This simple dinner will help you get through the busy holidays. Spaghetti Bolognese with a side dish of herbed zucchini is a simple, satisfying Italian meal. The gastronomic city of Bologna claims the origin of this dish, although it seems that every Italian cook has a favorite recipe.

While traditional meat sauce, or ragu, is usually left to simmer for hours, this recipe captures the essence without long hours of preparation. The secret is to let the onions, celery and carrots cook until they are sweet, and then add the crushed canned tomatoes.

Slicing vegetables very thin helps them to cook faster; frozen chopped onions help too. Serve with some crusty Italian bread warmed in the oven.

HELPFUL HINTS

Nutrition: This meal contains a total of 570 calories per serving with 27 percent of calories from fat.

Wine suggestion: In Bologna, they drink lambrusco with this dish, but that?s a bit sweet; try a chianti or val policella.

Cook quickly: Slice vegetables for Bolognese sauce and herbed zucchini at one time in a food processor fitted with a thin slicing blade.

To buy: 1 small bunch celery, 1/2 pound 96 percent lean ground beef, 1 orange, 1 package frozen chopped onions, 1 19-ounce can crushed tomatoes, 2 medium zucchini and 1 small package dried spaghetti.

Staples: Carrot, garlic, olive oil, dry white wine, dried oregano, salt and black peppercorns. Spaghetti Bolognese

3 tablespoons olive oil

1 cup frozen chopped onions

1 stalk celery, thinly sliced (1/2 cup)

1 carrot, thinly sliced (1/2 cup)

2 medium cloves garlic, crushed

6 ounces ground lean beef (95 percent lean)

1/4 cup dry white wine

2 cups canned tomatoes, crushed

Orange zest from 1 orange (about 1/2 teaspoon)

Salt and freshly ground black pepper

1/4 pound uncooked dry spaghetti

Place a large pot with 3 to 4 quarts water on to boil for pasta. Heat oil in a nonstick skillet over medium-high heat. Add onion, celery and carrot. Saut? 5 minutes, without browning. Add garlic and beef, crumbling the beef with a spoon. Saut? 2 minutes. Add white wine and cook until all of the liquid is absorbed, about 1 minute. Add the tomatoes and orange zest and gently simmer, uncovered, 15 minutes. Add salt and pepper to taste.

Meanwhile, add spaghetti to boiling water and cook 9 minutes or according to package instructions. Drain and serve sauce over pasta. Makes 2 servings.

Per serving: 510 calories (22 percent from fat), 12.4 g fat (3.1 g saturated, 7.0 g monounsaturated), 108 mg cholesterol, 29.5 g protein, 66.0 g carbohydrates, 6.9 g fiber, 135 mg sodium.

Herbed Zucchini

2 medium zucchini, thin sliced lengthwise (2 cups)

2 teaspoons olive oil

1 teaspoon dried oregano

Salt and freshly ground black pepper

Place zucchini in a microwave-safe bowl. Cover and microwave on high 3 minutes. Or, bring water to a boil in a saucepan and add the zucchini. Cook 5 minutes. Drain, leaving about 2 tablespoons water in the pan. Return zucchini to the bowl or pot. Toss the cooked zucchini with olive oil and oregano. Add salt and pepper to taste.

Per serving: 60 calories (72 percent from fat), 4.8 g fat (0.8 g saturated, 3.4 g monounsaturated), no cholesterol, 1.4 g protein, 4.1 g carbohydrates, 1.4 g fiber, 11 mg sodium.

SPAGHETTI BOLOGNESE

3 tablespoons olive oil

1 cup frozen chopped onions

1 stalk celery, thinly sliced (1/2 cup)

1 carrot, thinly sliced (1/2 cup)

2 medium cloves garlic, crushed

6 ounces ground lean beef (95 percent lean)

1/4 cup dry white wine

2 cups canned tomatoes, crushed

Orange zest from 1 orange (about 1/2 teaspoon)

Salt and freshly ground black pepper

1/4 pound uncooked dry spaghetti

Place a large pot with 3 to 4 quarts water on to boil for pasta. Heat oil in a nonstick skillet over medium-high heat. Add onion, celery and carrot. Saut? 5 minutes, without browning. Add garlic and beef, crumbling the beef with a spoon. Saut? 2 minutes. Add white wine and cook until all of the liquid is absorbed, about 1 minute. Add the tomatoes and orange zest and gently simmer, uncovered, 15 minutes. Add salt and pepper to taste.

Meanwhile, add spaghetti to boiling water and cook 9 minutes or according to package instructions. Drain and serve sauce over pasta. Makes 2 servings.

Per serving: 510 calories (22 percent from fat), 12.4 g fat (3.1 g saturated, 7.0 g monounsaturated), 108 mg cholesterol, 29.5 g protein, 66.0 g carbohydrates, 6.9 g fiber, 135 mg sodium.

HERBED ZUCCHINI

2 medium zucchini, thin sliced lengthwise (2 cups)

2 teaspoons olive oil

1 teaspoon dried oregano

Salt and freshly ground black pepper

Place zucchini in a microwave-safe bowl. Cover and microwave on high 3 minutes. Or, bring water to a boil in a saucepan and add the zucchini. Cook 5 minutes. Drain, leaving about 2 tablespoons water in the pan. Return zucchini to the bowl or pot. Toss the cooked zucchini with olive oil and oregano. Add salt and pepper to taste.

Per serving: 60 calories (72 percent from fat), 4.8 g fat (0.8 g saturated, 3.4 g monounsaturated), no cholesterol, 1.4 g protein, 4.1 g carbohydrates, 1.4 g fiber, 11 mg sodium.

Linda Gassenheimer is the author of 14 cookbooks including ?The Flavors of the Florida Keys.? Go to dinnerinminutes.com.

Source: http://www.theolympian.com/2013/01/02/2370752/meat-sauce-from-italy-satisfies.html

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Who is prone to Mesothelioma? | Noize.co.uk

Mesothelium could be the protective layer of the internal organs of the body. A rare kind of Cancer called Mesothelioma can get with the modification of those cells. Typically, the change can occur with exposure to asbestos (a substance commonly used for roofing purposes). Thus, it is a kind of cancer that develops in your lungs and stomach or in the pericardium of the center as well.

What type of Cancer?
This type of cancer can be benign or malignant. Harmless form of cancer is extremely rare. Cancerous type that occurs might be as a result of contact with asbestos with no relation to cigarette smoking. This is more prevalent among men in the place of girls.

Where it can occur?
Mesothelioma can happen in the stomach lining named mesothelioma of the stomach or peritoneal mesothelioma. The most often occurring being mesothelioma of the lungs of pleural mesothelioma affecting the mesothelium lining of the lungs.

Symptoms of Mesothelioma
Common symptoms are shortness of breath linked to pleural effusion (fluid between the lung wall) and the chest wall, chest pain, sweating temperature and unexplained weight loss.

Diagnosis
Analysis of this sort of cancer requires some medical history of the patient, X-ray, accompanied by CT scan of the patient who's thought with the same. The aim of the assessment procedure would require the delay of the outward symptoms with the best diagnosis of the suspected patient who could be exposed to asbestos within their health background.

Therapy
Treating this condition, see Read Much more might require the surgery, chemotherapy, radiotherapy and other treatment in line with the point of mesothelioma.

Ergo, the success rate is relied on the age of the patient, condition or the phase of infection, early analysis of the condition by your physician. Generally speaking this disease condition could possibly be dangerous if not treated once diagnosed and those exposed to asbestos need certainly to just take some preventive steps to reduce the chance of Mesothelioma.

Source: http://noize.co.uk/node/312

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Investing Legend Byron Wien Reveals 10 ... - Business Insider

Byron Wien started predicting surprises in 1986 when he was the Chief U.S. Investment Strategist at Morgan Stanley.

He continues the tradition today as Vice Chairman at Blackstone.

His "Ten Surprises for 2013," which he believes have a better than 50 percent probability of happening, have a bearish slant from the perspective of the U.S. investor.? He sees stocks falling while commodity prices rise.

His prediction for Iran may scare some people, but he is a bit more hopeful for immigration reform in the U.S.

Without further ado ...

Source: http://www.businessinsider.com/byron-wiens-10-surprises-for-2013-2013-1

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How to Lose Weight and Detox with Ginger - Health News and ...

istock

Ginger?you either love it or hate it, right? An abundance of new evidence suggests people in both categories should consider getting more ginger into their diets, as ginger seems to play an important, measurable role in weight management and gastrointestinal health, and has anti-inflammatory and detoxifying benefits as well. Oh, and it might just make you prettier.

Last summer, a study by researchers at the Institute for Human Nutrition at Columbia University found that adding a hot ginger beverage to the diet of human subjects made them feel fuller after a meal and less likely to eat more later. ?The results, showing enhanced thermogenesis and reduced feelings of hunger with ginger consumption, suggest a potential role of ginger in weight management,? the researchers said, calling for additional studies to confirm the findings.

For centuries, ginger has been the go-to root for a wide range of GI distresses. Researchers believe its compounds stimulate digestive secretions, improve intestinal muscle tone, and help move food through the gastrointestinal tract.

It?s safe to take ginger in small doses (less than 1,000 milligrams) for a short period of time during pregnancy, says Joyce Frye, a doctor of osteopathy and clinical assistant professor at the Center for Integrative Medicine at the University of Maryland School of Medicine in Baltimore.

Got bad period cramps? Try ginger tea. A study in the Journal of Alternative and Complementary Medicine found that ginger was as effective as ibuprofen for relieving painful periods. Just steep 2 tablespoons fresh ginger root in water for 15 minutes, strain, and enjoy with honey or lemon.

If bumpy flights and long car trips make your stomach turn, try a piece of crystallized or pickled ginger. Ginger worked better than dimenhydrinate (the active ingredient in over-the-counter motion-sickness meds) at preventing and treating motion sickness, according to Brigham Young University research.

Fresh ginger?sipped in tea or eaten straight-up?is best, says Sari Greaves, RD, of New York Presbyterian Hospital?Weill Cornell Medical Center in New York City. I suggest you make your own low-sugar, super-spicy ginger?ale.

But ginger in other forms (dried, powdered, cooked) can be effective too. A tea to try: Yogi Lemon Ginger Tea and Traditional Medicinals? Organic Ginger Aid ($4 to $5; grocery stores). Ginger ale? Most brands have little or no real ginger and lots of high-fructose corn syrup.

Related stories:

Source: http://news.health.com/2012/12/31/how-to-lose-weight-and-detox-with-ginger/

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